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Neal Davies Ph.D. R.Ph.
Associate Professor
Director of Undergraduate and Professional Research
Department of Pharmaceutical Sciences
College of Pharmacy
Washington State University
Pullman, WA 99164-6534

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Office (509) 335-4754
Lab: (509) 335-8816
Cell: (509) 432-9824
Fax: (509) 335-5902
Email: ndavies@wsu.edu

Other Affiliations: Pharmacology/Toxicology Graduate Program Center for Integrated Biotechnology Cancer Prevention and Research Center Center for Sustaining Agriculture and Natural Resources

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Education:

BSc.(Pharm) Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Canada

Ph.D Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta, Canada

P.D.F. Faculty of Medicine, Department of Pharmacology and Therapeutics University of Calgary, Canada

Clinical Pharmacist Registered with the Pharmacy Examining Board of Canada and Alberta Pharmaceutical Association.

Research Interests:

Pharmacometrics of Anti-inflammatory / Anti-Cancer Drugs and Phytochemicals

Dr. Davies' research program in the Department of Pharmaceutical Sciences aims to investigate the factors that influence variability in drug response through an understanding of drug delivery and disposition (pharmacokinetics) as well as action to optimize the use of anti-inflammatory and anti-cancer agents. The Davies laboratory explores factors affecting the dissolution, stability, release and safety and efficacy of anti-inflammatory drugs and anti-cancer drugs, the role of liver and renal metabolism in determining effects of drugs, advances in anti-inflammatory development such as the COX-2 inhibitors, new therapeutic indications for anti-inflammatory drugs, new approaches to the treatment of pain and new avenues for the treatment of hyperlipidemia, hepatitis, colorectal cancer and inflammation associated with gastrointestinal tract and arthropathies. Dr. Davies laboratory uses a variety of sample analyses, specializing in HPLC/MS analyses, including: Bioanalytical Sample Analysis, Quantitative Analysis, Pharmacokinetic Analysis, High-Throughput Drug Discovery, Analytical Methods Development and Validation, Structure Elucidation including Metabolite Identification and Stability Impurity Indentification.

More recent investigations have focused on block polymeric micelles for drug delivery and on plant secondary metabolites and metabolism and disposition of anti-inflammatory/anti-cancer nutraceuticals and phytochemicals including stilbenes and flavonoids, nutraceuticals and animal models and scaling their impact on human health.

Interested post-docs and graduate students are encouraged to contact me to discuss research opportunities in my lab.

Teaching: My primary teaching responsibility is Pharmaceutics III (Pharmacokinetics) (PharmS533) with additional graduate level teaching to students in the Pharmacology/Toxicology Graduate Program.

Selected Publications 1991-present (over 100 available upon request)
2004
Davies NM. Chiral Inversion p351-392. In Chirality and Drug Design and Development Marcel Dekker, Inc., New York Reddy and Mehvar Eds 2004.

Feddah MR, Davies NM. Alternative Methods of Particle Size Analysis of Metered Dose Inhaler Aerosols. Journal of Medical Sciences 3 (2): 1-7, 2004

Davies NM, Good RL, Roupe KA, Yanez JA. Cyclooxygenase-3: Axiom, Dogma, Anomaly, Enigma or Splice Error?- Not as Easy As 1, 2, 3. Journal of Pharmacy and Pharmaceutical Sciences 7(2): 217-226, 2004.

Teng XW, Davies NM. High-Performance Liquid Chromatographic Analysis of Selective Cyclooxygenase-1 Inhibitor SC-560 in Rat Serum: Application to Pharmacokinetic Studies. Journal of Pharmaceutical and Biomedical Analysis: 2004; 35(5):1143-1147.

Roupe KA, Teng XW, Fu X, Meadows GG, Davies NM. Determination of Piceatannol in Rat Serum and Liver Microsomes: Pharmacokinetics and Phase I and II Biotransformation. Biomedical Chromatography. 2004; 18: 486-491.

Davies NM. Degradation and Metabolism of Mometasone Furoate in Humans: Influence of Reversible, Sequential Metabolism, and Ionic Strength. Journal of Pharmaceutical Sciences 2004; 93(12):2877-2881.

Davies NM, Jamali F. COX-2 Inhibitors and Cardiac Toxicity: Getting to the Heart of the Matter. J Pharm Pharm Sci 2004; 7(3):332-336.

2005
Yáñez JA, Teng XW, Roupe KA, Davies NM. Stereospecific High-Performance Liquid Chromatographic Analysis of Hesperetin in Biological Matrices Journal of Pharmaceutical and Biomedical Analysis 2005; 37: 591-595.

Meier-Kriesche H-U, Davies NM, Grinyó J, Heading R, Mamelok R, Oellerich M, Wijngaard P, Maes B. Mycophenolate sodium does not reduce the incidence of GI adverse events compared with mycophenolate mofetil. Am J Transplant 2005; 5: 1164-1166.

Roupe KA, Halls S, Davies NM. Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics. Journal of Pharmaceutical and Biomedical Analysis. 2005; 38(1): 148-154.

Teng XW, Davies NM. Fukuda C, Good RL, Fariss MW,Pharmacokinetics and Tissue Distribution of Alpha-Tocopheryl Hemisuccinate Formulations in the Rat. Biopharmaceutics and Drug Disposition 2005;26(5):195-203.

Yanez, JA, Davies NM. Stereospecific High-Performance Liquid Chromatographic Analysis of Naringenin. Journal of Pharmaceutical and Biomedical Analysis 2005; 39(1-2): 164-169.

Good RL, Roupe KA, Fukuda C, Clifton GD, Fariss MW, Davies NM. Direct high-performance liquid chromatographic analysis of D-tocopheryl acid succinate and derivatives. Journal of Pharmaceutical and Biomedical Analysis 2005; 2005; 39(1-2): 33-38.

Roupe KA, Helms GL , Halls SC, Yáñez JA, Davies NM. Enzymatic Synthesis and HPLC Analysis of Rhapontigenin: Applications to Drug Metabolism, Pharmacokinetics and Anti-Cancer Activity. Journal of Pharmacy and Pharmaceutical Sciences 2005; 8(3): 374-386.

Megalli S, Atkan F, Davies NM, Roufogalis BD. Phytopreventative Anti-Hyperlipidemic Effects of Gynostemma pentaphyllum in Rats" Journal of Pharmacy and Pharmaceutical Sciences 2005; 8(3): 507-515.

Gates BJ, Nguyen TT, Setter S, Davies NM. Meloxicam: a reappraisal of Efficacy and safety. Expert Opinion in Pharmacotherapy. 2005; 6(12): 21117-2140.

Torres CA, Davies NM, Yanez JA, Andrews PK. Disposition of Selected Flavonoids in Fruit Tissues of Various Tomato Genotypes. Journal of Agriculture and Food Chemistry. 2005; 53(24):9536-9543.

2006
Roupe KA, Remsberg C, Yanez JA, Davies NM. Pharmacometrics of Stilbenes: Seguing Towards the Clinic. Current Clinical Pharmacology 2006 1(1): 81-101

Yáñez JA, Teng XW, Roupe KA, Davies NM. Alternative Methods for Assessing Experimental Colitis In Vivo and Ex Vivo. Journal of Medical Sciences in 2006; 6(3):356-365.

Torres CA, Andrews PK, Davies NM, . Physiological and Metabolic Responses of Fruit Exocarp of tomato (Lycopersicon esculentum Mill) mutants to natural photooxidative conditions. Journal of Experimental Botany 2006; 57(9): 1933-1947.

Gates BJ Davies NM, Amplichip for Cytochrome P450 Genotyping: The Epoch of Personalized Prescriptions. Hospital Pharmacy. 2006; 41(4): 442-452

Roupe KA, Yáñez JA, Teng XW, Davies NM. Pharmacokinetics of Selected Stilbenes, Rhapontigenin, Piceatannol and Pinosylvin in Rats. Journal of Pharmacy and Pharmacology 2006; 8(11): 1443-1450

Davies NM, Reynolds JK, Undeberg MR, Gates BJ, Ohgami Y, Vega-Villa, KR. Minimizing Risks of NSAIDs: Cardiovascular, Gastrointestinal and Renal Expert Review of Neurotherapeutics 2006 6(11): 1643-1655.

Megalli S, Davies NM, Roufogalis BD Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Rat. Journal of Pharmacy and Pharmaceutical Sciences 2006; 9(2): 281-291.

2007
Yáñez JA, Miranda ND, Remsberg CM, Ohgami Y, Davies NM. Stereospecific High-Performance Liquid Chromatographic Analysis of Eriodictyol in Urine Journal of Pharmaceutical and Biomedical Analysis 2007; 43 : 255-262.

Remsberg CM, Yáñez JA, Roupe KA, Davies NM. High-Performance Liquid Chromatographic Analysis of Pterostilbene in Biological Fluids Using Fluorescence Detection Journal of Pharmaceutical and Biomedical Analysis 2007: 43: 250-254

Yanez JA, Andrews PK, Davies NM. Methods of Analysis of Chiral Flavonoids. J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 848: 159-181.

Hesse C, Razmovski-Naumovski C, Duke CC, Davies NM, Roufogalis BD. Phytopreventative Effects of Gynostemma pentaphyllum Against Acute Indomethacin-Induced Gastrointestinal and Renal Toxicity in Rats Phytotherapy Research 2007; 21(6): 523-530

Davies NM, Grinyó J, Heading R, Maes B, Meier-Kriesche HU, Oellerich M. Gastrointestinal side effects of mycophenolic acid in renal transplant patients: a reappraisal. Nephrology, Dialysis and Transplantation 2007; 22(9): 2440-24481.

Xiong MP, Forrest ML, Ton G, Zhao A. Davies NM, Kwon GS. Poly (Aspartate-g-PEI800), a Polyethylenimine Analogue of Low Toxicity and High Transfection Effiiciency for Gene Delivery. Biomaterials: 2007; 28 (32): 4889-4900.

2008
Gray VA, Hickey AJ, Ballmer P, Davies NM, Dunbar C, Foster TS, Olsson BL Sakagami M, Shah V, Smurthwaite MJ, Veranth J. The Inhalation Ad Hoc Advisory Panel for the USP Performance Tests of Inhalation Dosage Forms. Pharmacopeial Forum 2008: 34(2) :2-8.

Yáñez JA, Remsberg CM, Vega-Villa KR , Mirand ND, Navas J, McCormick D, Hughes K, Temple C, Ohgami Y, Martinez SA. Davies NM. Pharmacological Evaluation of Glyco-Flex III and Constituents on Canine Chondrocytes. Journal of Medical Sciences 2008; 8(1): 1-14.

Yáñez JA, Ohgami Y, Kwon GS, Davies NM, Forrest ML. Pharmacometrics and Delivery of Novel Nanoformulated PEG-b-Poly(e-caprolactone) Micelles of Rapamycin. Cancer Chemotherapy and Pharmacology 2008; 61(1): 133-144.

Remsberg CM, . Yáñez JA, Ohgami Y, Vega-Villa KR, Rimando AM, Davies NM Pharmacometrics of Pterostilbene: Pre-Clinical Pharmacokinetics and Metabolism, Anti-Cancer, Anti-Inflammatory, Anti-Oxidant, and Analgesic Activity. Phytotherapy Research 2008; 22 (2): 169-179.

Vega-Villa KR, Remsberg CM, Yáñez JA,, Takemoto JK, Forrest ML, Davies NM Clinical Toxicities of Nanocarrier Systems Advanced Drug Delivery Reviews 2008:60: 133-144.

Yáñez JA, Remsberg CM, Miranda ND, Andrews PK, Vega-Villa KR, Davies NM. Stereospecific Pharmacokinetics of Selected Chiral Flavonoids: Hesperetin, Naringenin, and Eriodictyol and their Content in Fruit Juices. Biopharmaceutics and Drug Disposition 2008; 29(2): 63-82

Forrest ML, Yáñez JA, Remsberg CM, Ohgami Y, Kwon GS, Davies NM Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity. Pharmaceutical Research 2008; 25(1): 194-206.

Vega-Villa KR, Yáñez JA, Remsberg CM, Ohgami Y, Davies NM. Stereospecific High-Performance Liquid Chromatographic Validation of Homoeriodictyol in Serum and Yerba Santa (Eriodictyon glutinosum) Journal of Pharmaceutical and Biomedical Analysis 2008; 46:971-974

Xiong MP, Forrest MC, Yanez JA, Remsberg CM, Kwon GS, Davies NM. Formulation of a Geldanamycin Prodrug in MPEG-b-PCL Micelles Greatly Enhances Tolerability and Pharmacokinetics in Rat. Journal of Controlled Release In 2008, 129(1):33-00.

Takemoto JK, Reynolds JK, Remsberg CM, Davies NM. Clinical Pharmacokinetic and Pharmacodynamic Profile of Etoricoxib. Clinical Pharmacokinetics In press: 2008

Ramos Escudero M, Ramos Escudero DF, Remsberg CR, Takemoto JK, Davies NM, Yáñez JA Identification of Polyphenols and Anti-Oxidant Capacity of Piper aduncum L. TOBCJ 2008: 1:18-21.

Wang TTY, Hudson TS, Wang TC, Remsberg CM, Davies NM,Takahashi Y, Kim YS , Seifried H , Vinyard BT, Perkins SN, Hursting SD. Differential Effects of Resveratrol on Androgen-responsive LNCaP Human Prostate Cancer Cells In Vitro and In Vivo Carcinogenesis 2008; June26 (epublished ahead of print).

Vega-Villa KR, Remsberg CM, Podelnyk KL, Davies NM. Stereospecific High Performance Liquid Chromatographic Assay of Isosakuranetin in Rat Urine Journal of Chromatography B: Biomedical Applications, In press 2008

Xiong MP,Yáñez JA, Kwon GS, Davies NM, Forrest ML. A Cremophor-Free Formulation for Tanespimycin (17-AAG) using PEO-b-PDLA Micelles: Characterization and Pharmacokinetics in Rats. Journal of Pharmaceutical Sciences In press: 2008.

Takemoto JK, Remsberg CM, Yanez JA, Vega-Villa KR, Davies NM. Stereospecific Analysis of Sakuranetin by High-Performance Liquid Chromatography Journal of Chromatography B: In Press 2008

Mejia-Meza EI, Yanez JA, Remsberg CM, Davies NM, Rasco B, Younce F, Clary C. Improving Nutritional Value of Dried Blueberries (Vaccinium Corymbosum L.) Combining Microwave-Vacuum, Hot-Air Drying AND Freeze Drying Technologies. International Journal of Food Engineering 2008; May 1 (epublished ahead of print).

Vega-Villa KR, Remsberg CM, Yanez JA, Takemoto JK, Andrews PK, Davies NM. Stereospecific Analysis of taxifolin by High-Performance Liquid Chromatography Application in Pharmacokinetics Biomedical Chromatography Accepted 2008.

Patents:

Australian Provisional Patent Application No. 2004901694 Entitled "Composition" filed on the 30th March 2004. Subsequently filed as International Patent Application Number PCT/AU2004/00442

Australian Provisional Patent Application No. 2005901463 filed on the 24th March 2005 and entitled Method of Treatment of Carcinomas.

Australian Provisional Patent Application No. 2005901462 filed on the 24th March 2005 and entitled Metal Complexes (Copper ACM complexes)

United States Patent Application filed July 9, 2008 Micellular Encapsulation of Tanespimycin.

Ongoing and Previous Support:
http://www.sabinsa.com/
http://www.shimadzu.com/
www.usp.org
www.afpenet.org
http://www.rsmedical.com/
http://impact.wsu.edu/
http://www.red-raspberry.org/

The Organic Center

Washington State Tree Fruit Commission

Food Science Corporation Vetri Science


Wisconsin Alumni Research Foundation


National Institutes of Health


Attorney General’s Office, State of Washington


American Cancer Society Institutional Research Grant


Australian Research Council Grant


Arrow Pharmaceuticals


Nature Vet

Some Davies Laboratory Alumni Doctor of Philosophy Students
Jaime A. Yáñez, Ph.D. "Pharmacometrics and Metabolonomics of Selected Chiral Flavanoids" Awarded Ph.D. May 2008
	Now: Dr. Jaime A. Yáñez Senior Scientist Drug Metabolism and Pharmacokinetics Schering-Plough Research Institute 2000 Galloping Hill Rd. Kenilworth, NJ 07033 USA Mail Stop: K-15-3 3700 (Office D-328C) Phone: 908-740-3270 Email: jaime.yanez@spcorp.com
Kathryn A. Roupe Ph.D. “Pharmacometrics of Selected Stilbenes: Piceatannol, Pinosylvin and Rhapontigenin” Awarded Ph.D. December 2005.
	Now: Dr.Kathryn Roupe. Senior Pharmacokineticist MDS Pharma Services 621 Rose Street Lincoln, NE 68502 USA Email: Kathryn.roupe@mdsinc.com

Xiao Wei Teng Ph.D. “Metabolism and Degradation of Mometasone Furoate” Awarded PhD 2002.
	Now: Dr. Xiao Wei Teng, BRI Biopharmaceutical Research Inc. 3650 WestbrookMall Vancouver, BC, Canada V652L2 Email:xteng@bripharm.com

Majid R. Feddah PhD. “In Vitro Characterization of Glucocorticoid Aerosol Formulations.” Awarded Ph.D 2002
	Now: Dr. Majid Feddah ARABIO The Arab Company for Biopharmaceutical Products P.O.Box: 55164, Jeddah 21534, Saudi Arabia E-mail:mfeddah@arabio.com
	Pharmacology & Toxicology Doctoral Student Karina Vega-Villa BSc. Ph.D. Student Email: kvilla@wsu.edu
	Pharmacology & Toxicology Doctoral Student Jody Takemoto BS & BA; Ph.D. Student Email: jtakemoto@wsu.edu

MASTERS
Abdallah Abu-Mellal MPharm
“N-Acetyl-Beta-glucosonamidase: Influence of Cylooxygenase Inhibition”.
Awarded MPharm. 2002.

HONORS STUDENTS
Joseph Saleh B.Pharm(Hons) 2nd Class
“Non-Steroidal Anti-inflammatory Drugs and the GI Tract” 1999.

Irene Stafides B.Pharm(Hons) 1st Class
“Evaluation of the Gastrointestinal and Renal Toxicity of Anti-Inflammatory Drugs in Experimental Models” 2000.

Andrew Siu B.Pharm(Hons) 2nd Class
“Granulocyte Marker Protein: A Novel Diagnostic Marker of Intestinal Disease” 2000.

Pharm.D. TRAINEES

Connie Remsberg BSc
PharmD. Candidate
Ph.D. Student

Email:cremsberg@wsu.edu

Trang Nguyen Pharm.D. Washington State University, College of Pharmacy
“Pharmacometric Investigations of Phytochemicals” 2005

Martin deLeeuw Pharm.D. University of Utrecht, Faculty of Pharmacy, Netherlands
“Pharmacometric Investigation of Azmacort®” 2000-2001.

Thijs Gudde Pharm. D. University of Utrecht, Faculty of Pharmacy, Netherlands
“Pharmacometric Optimisation of Becotide®” 2000-2001.

Cristina Hesse Pharm. D. University of Genoa, Faculty of Pharmacy, Italy
“Isolation and Purification of Gynostemma pentaphyllum Fractions and their Pharmacological Activity”. 2000-2001.

POST-DOCTORAL FELLOWS

Chie Fukuda Ph.D. 2003-2005
	Now: Dr. Chie Fukuda Associate Chief Researcher Biological Research Laboratories SANKYO CO, LTD 1-2-58 hiromachi, Shinagawa-ku Tokyo 140-8710 Japan Email: fukuda_chie@sankyo.co.jp
	Post-Doctoral Fellow Dr. Yusuke Ohgami 2006-present Email: ohgami@wsu.edu

SUMMER UNDERGRADUATE RESEARCH FELLOWS

Jaime A. Yáñez University of Idaho, Department of Food Sciences 2002, 2003, 2004

Renee L. Woody (Good) Washington State University College of Veterinary Medicine 2004

Connie M. Remsberg University of Idaho, College of Science 2005, 2006, 2007

Nicole D. Miranda University of Concepcion, Chile College of Engineering 2005, 2006, 2007

Rebecca Bertram Gonzaga University College of Science 2008

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