Neal M. Davies Ph.D. R.Ph.
Associate Professor
Director of Pharmaceutical Sciences Graduate Program
Director of Summer Undergraduate Research Fellowship (SURF) Program
College of Pharmacy
Washington State University
Pullman, WA 99164-6534
Office (509) 335-4754
Lab: (509) 335-8816
Cell: (509) 432-9824
Fax: (509) 335-5902
Email: ndavies@wsu.edu
Education:
BSc.(Pharm) Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Canada
Ph.D Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta, Canada
P.D.F. Faculty of Medicine, Department of Pharmacology and Therapeutics University of Calgary, Canada
Clinical Pharmacist Registered with the Pharmacy Examining Board of Canada and Alberta Pharmaceutical Association.
Research Interests:
Pharmacometrics of Anti-inflammatory / Anti-Cancer Drugs, Phytochemicals and Orthopedic Implants
Dr. Davies' research program in the Department of Pharmaceutical Sciences aims to investigate the factors that influence variability in drug response through an understanding of drug delivery and disposition (pharmacokinetics) as well as action to optimize the use of anti-inflammatory and anti-cancer agents. The Davies laboratory explores factors affecting the dissolution, stability, release and safety and efficacy of anti-inflammatory drugs and anti-cancer drugs, the role of liver and renal metabolism in determining effects of drugs, advances in anti-inflammatory development such as the COX-LOX inhibitors, new therapeutic indications for anti-inflammatory drugs, new approaches to the treatment of pain and new avenues for the treatment of hyperlipidemia, hepatitis, colorectal cancer and inflammation associated with gastrointestinal tract and arthropathies. Dr. Davies laboratory uses a variety of sample analyses, including atomic absorption spectrophotometry, high performance liquid chromatography, specializing in HPLC/MS analyses, including: Bioanalytical Sample Analysis, Quantitative Analysis, Pharmacokinetic Analysis, High-Throughput Drug Discovery, Analytical Methods Development and Validation, Structure Elucidation including Metabolite Identification and Stability Impurity Indentification.
More recent investigations have focused on block polymeric micelles for drug delivery of hydrophobic xenobiotics and on plant secondary metabolites and metabolism and disposition of anti-inflammatory/anti-cancer nutraceuticals and phytochemicals including stilbenes and flavonoids, nutraceuticals in animal models and scaling their impact on human health. In addition ceramic and metallic orthopedic bone implant studies are also being undertaken.
Interested post-docs and graduate students are encouraged to contact me to discuss research opportunities in my lab.
Teaching:
My primary teaching responsibility is Pharmaceutics III (Pharmacokinetics) (PharmD528) with additional graduate level teaching to students in the Pharmaceutical Sciences Graduate Program.
Selected Publications 1991-present (over 130 available upon request)
2004
Davies NM. Chiral Inversion p351-392. In Chirality and Drug Design and Development Marcel Dekker, Inc., New York Reddy and Mehvar Eds 2004.
Feddah MR, Davies NM. Alternative Methods of Particle Size Analysis of Metered Dose Inhaler Aerosols. Journal of Medical Sciences 3 (2): 1-7, 2004
Davies NM, Good RL, Roupe KA, Yanez JA. Cyclooxygenase-3: Axiom, Dogma, Anomaly, Enigma or Splice Error?- Not as Easy As 1, 2, 3. Journal of Pharmacy and Pharmaceutical Sciences 7(2): 217-226, 2004.
Teng XW, Davies NM. High-Performance Liquid Chromatographic Analysis of Selective Cyclooxygenase-1 Inhibitor SC-560 in Rat Serum: Application to Pharmacokinetic Studies. Journal of Pharmaceutical and Biomedical Analysis: 2004; 35(5):1143-1147.
Roupe KA, Teng XW, Fu X, Meadows GG, Davies NM. Determination of Piceatannol in Rat Serum and Liver Microsomes: Pharmacokinetics and Phase I and II Biotransformation. Biomedical Chromatography. 2004; 18: 486-491.
Davies NM. Degradation and Metabolism of Mometasone Furoate in Humans: Influence of Reversible, Sequential Metabolism, and Ionic Strength. Journal of Pharmaceutical Sciences 2004; 93(12):2877-2881.
Davies NM, Jamali F. COX-2 Inhibitors and Cardiac Toxicity: Getting to the Heart of the Matter. J Pharm Pharm Sci 2004; 7(3):332-336.
2005
Yáñez JA, Teng XW, Roupe KA, Davies NM. Stereospecific High-Performance Liquid Chromatographic Analysis of Hesperetin in Biological Matrices Journal of Pharmaceutical and Biomedical Analysis 2005; 37: 591-595.
Meier-Kriesche H-U, Davies NM, Grinyó J, Heading R, Mamelok R, Oellerich M, Wijngaard P, Maes B. Mycophenolate sodium does not reduce the incidence of GI adverse events compared with mycophenolate mofetil. Am J Transplant 2005; 5: 1164-1166.
Roupe KA, Halls S, Davies NM. Determination and assay validation of pinosylvin in rat serum: application to drug metabolism and pharmacokinetics. Journal of Pharmaceutical and Biomedical Analysis. 2005; 38(1): 148-154.
Teng XW, Davies NM. Fukuda C, Good RL, Fariss MW,Pharmacokinetics and Tissue Distribution of Alpha-Tocopheryl Hemisuccinate Formulations in the Rat. Biopharmaceutics and Drug Disposition 2005;26(5):195-203.
Yanez, JA, Davies NM. Stereospecific High-Performance Liquid Chromatographic Analysis of Naringenin. Journal of Pharmaceutical and Biomedical Analysis 2005; 39(1-2): 164-169.
Good RL, Roupe KA, Fukuda C, Clifton GD, Fariss MW, Davies NM. Direct high-performance liquid chromatographic analysis of D-tocopheryl acid succinate and derivatives. Journal of Pharmaceutical and Biomedical Analysis 2005; 2005; 39(1-2): 33-38.
Roupe KA, Helms GL , Halls SC, Yáñez JA, Davies NM. Enzymatic Synthesis and HPLC Analysis of Rhapontigenin: Applications to Drug Metabolism, Pharmacokinetics and Anti-Cancer Activity. Journal of Pharmacy and Pharmaceutical Sciences 2005; 8(3): 374-386.
Megalli S, Atkan F, Davies NM, Roufogalis BD. Phytopreventative Anti-Hyperlipidemic Effects of Gynostemma pentaphyllum in Rats" Journal of Pharmacy and Pharmaceutical Sciences 2005; 8(3): 507-515.
Gates BJ, Nguyen TT, Setter S, Davies NM. Meloxicam: a reappraisal of Efficacy and safety. Expert Opinion in Pharmacotherapy. 2005; 6(12): 21117-2140.
Torres CA, Davies NM, Yanez JA, Andrews PK. Disposition of Selected Flavonoids in Fruit Tissues of Various Tomato Genotypes. Journal of Agriculture and Food Chemistry. 2005; 53(24):9536-9543.
2006
Roupe KA, Remsberg C, Yanez JA, Davies NM. Pharmacometrics of Stilbenes: Seguing Towards the Clinic. Current Clinical Pharmacology 2006 1(1): 81-101
Yáñez JA, Teng XW, Roupe KA, Davies NM. Alternative Methods for Assessing Experimental Colitis In Vivo and Ex Vivo. Journal of Medical Sciences in 2006; 6(3):356-365.
Torres CA, Andrews PK, Davies NM, . Physiological and Metabolic Responses of Fruit Exocarp of tomato (Lycopersicon esculentum Mill) mutants to natural photooxidative conditions. Journal of Experimental Botany 2006; 57(9): 1933-1947.
Gates BJ Davies NM, Amplichip for Cytochrome P450 Genotyping: The Epoch of Personalized Prescriptions. Hospital Pharmacy. 2006; 41(4): 442-452
Roupe KA, Yáñez JA, Teng XW, Davies NM. Pharmacokinetics of Selected Stilbenes, Rhapontigenin, Piceatannol and Pinosylvin in Rats. Journal of Pharmacy and Pharmacology 2006; 8(11): 1443-1450
Davies NM, Reynolds JK, Undeberg MR, Gates BJ, Ohgami Y, Vega-Villa, KR. Minimizing Risks of NSAIDs: Cardiovascular, Gastrointestinal and Renal Expert Review of Neurotherapeutics 2006 6(11): 1643-1655.
Megalli S, Davies NM, Roufogalis BD Anti-Hyperlipidemic and Hypoglycemic Effects of Gynostemma pentaphyllum in the Zucker Rat. Journal of Pharmacy and Pharmaceutical Sciences 2006; 9(2): 281-291.
2007
Yáñez JA, Miranda ND, Remsberg CM, Ohgami Y, Davies NM. Stereospecific High-Performance Liquid Chromatographic Analysis of Eriodictyol in Urine Journal of Pharmaceutical and Biomedical Analysis 2007; 43 : 255-262.
Remsberg CM, Yáñez JA, Roupe KA, Davies NM. High-Performance Liquid Chromatographic Analysis of Pterostilbene in Biological Fluids Using Fluorescence Detection Journal of Pharmaceutical and Biomedical Analysis 2007: 43: 250-254
Yanez JA, Andrews PK, Davies NM. Methods of Analysis of Chiral Flavonoids. J Chromatogr B Analyt Technol Biomed Life Sci. 2007; 848: 159-181.
Hesse C, Razmovski-Naumovski C, Duke CC, Davies NM, Roufogalis BD. Phytopreventative Effects of Gynostemma pentaphyllum Against Acute Indomethacin-Induced Gastrointestinal and Renal Toxicity in Rats Phytotherapy Research 2007; 21(6): 523-530
Davies NM, Grinyó J, Heading R, Maes B, Meier-Kriesche HU, Oellerich M. Gastrointestinal side effects of mycophenolic acid in renal transplant patients: a reappraisal. Nephrology, Dialysis and Transplantation 2007; 22(9): 2440-24481.
Xiong MP, Forrest ML, Ton G, Zhao A. Davies NM, Kwon GS. Poly (Aspartate-g-PEI800), a Polyethylenimine Analogue of Low Toxicity and High Transfection Effiiciency for Gene Delivery. Biomaterials: 2007; 28 (32): 4889-4900.
2008
Gray VA, Hickey AJ, Ballmer P, Davies NM, Dunbar C, Foster TS, Olsson BL Sakagami M, Shah V, Smurthwaite MJ, Veranth J. The Inhalation Ad Hoc Advisory Panel for the USP Performance Tests of Inhalation Dosage Forms. Pharmacopeial Forum 2008: 34(2) :2-8.
Yáñez JA, Remsberg CM, Vega-Villa KR , Mirand ND, Navas J, McCormick D, Hughes K, Temple C, Ohgami Y, Martinez SA. Davies NM. Pharmacological Evaluation of Glyco-Flex III and Constituents on Canine Chondrocytes. Journal of Medical Sciences 2008; 8(1): 1-14.
Yáñez JA, Ohgami Y, Kwon GS, Davies NM, Forrest ML. Pharmacometrics and Delivery of Novel Nanoformulated PEG-b-Poly(e-caprolactone) Micelles of Rapamycin. Cancer Chemotherapy and Pharmacology 2008; 61(1): 133-144.
Remsberg CM, . Yáñez JA, Ohgami Y, Vega-Villa KR, Rimando AM, Davies NM Pharmacometrics of Pterostilbene: Pre-Clinical Pharmacokinetics and Metabolism, Anti-Cancer, Anti-Inflammatory, Anti-Oxidant, and Analgesic Activity. Phytotherapy Research 2008; 22 (2): 169-179.
Vega-Villa KR, Remsberg CM, Yáñez JA,, Takemoto JK, Forrest ML, Davies NM Clinical Toxicities of Nanocarrier Systems Advanced Drug Delivery Reviews 2008:60: 133-144.
Yáñez JA, Remsberg CM, Miranda ND, Andrews PK, Vega-Villa KR, Davies NM. Stereospecific Pharmacokinetics of Selected Chiral Flavonoids: Hesperetin, Naringenin, and Eriodictyol and their Content in Fruit Juices. Biopharmaceutics and Drug Disposition 2008; 29(2): 63-82
Forrest ML, Yáñez JA, Remsberg CM, Ohgami Y, Kwon GS, Davies NM Paclitaxel Prodrugs with Sustained Release and High Solubility in Poly(ethylene glycol)-b-poly(ε-caprolactone) Micelle Nanocarriers: Pharmacokinetic Disposition, Tolerability, and Cytotoxicity. Pharmaceutical Research 2008; 25(1): 194-206.
Vega-Villa KR, Yáñez JA, Remsberg CM, Ohgami Y, Davies NM. Stereospecific High-Performance Liquid Chromatographic Validation of Homoeriodictyol in Serum and Yerba Santa (Eriodictyon glutinosum) Journal of Pharmaceutical and Biomedical Analysis 2008; 46:971-974
Xiong MP, Forrest MC, Yanez JA, Remsberg CM, Kwon GS, Davies NM. Formulation of a Geldanamycin Prodrug in MPEG-b-PCL Micelles Greatly Enhances Tolerability and Pharmacokinetics in Rat. Journal of Controlled Release In 2008, 129(1):33-40.
Takemoto JK, Reynolds JK, Remsberg CM, Vega-Villa KR, Davies NM. Clinical pharmacokinetic and pharmacodynamic profile of etoricoxib.Clin Pharmacokinet. 2008;47(11):703-720.
Ramos Escudero M, Ramos Escudero DF, Remsberg CR, Takemoto JK, Davies NM, Yáñez JA Identification of Polyphenols and Anti-Oxidant Capacity of Piper aduncum L. TOBCJ 2008: 1:18-21.
Wang TTY, Hudson TS, Wang TC, Remsberg CM, Davies NM,Takahashi Y, Kim YS , Seifried H , Vinyard BT, Perkins SN, Hursting SD. Differential Effects of Resveratrol on Androgen-responsive LNCaP Human Prostate Cancer Cells In Vitro and In Vivo Carcinogenesis 2008; 29(10): 2001-2010
Vega-Villa KR, Remsberg CM, Podelnyk KL, Davies NM. Stereospecific High Performance Liquid Chromatographic Assay of Isosakuranetin in Rat Urine Journal of Chromatography B: Biomedical Applications, 2008: 875:142-147.
Takemoto JK, Remsberg CM, Yanez JA, Vega-Villa KR, Davies NM. Stereospecific Analysis of Sakuranetin by High-Performance Liquid Chromatography Journal of Chromatography B: 2008: 875:136-141.
Mejia-Meza EI, Yanez JA, Remsberg CM, Davies NM, Rasco B, Younce F, Clary C. Improving Nutritional Value of Dried Blueberries (Vaccinium Corymbosum L.) Combining Microwave-Vacuum, Hot-Air Drying and Freeze Drying Technologies. International Journal of Food Engineering 2008; 4(6): 1-6.
2009
Xiong MP,Yáñez JA, Kwon GS, Davies NM, Forrest ML. A Cremophor-Free Formulation for Tanespimycin (17-AAG) using PEO-b-PDLA Micelles: Characterization and Pharmacokinetics in Rats. Journal of Pharmaceutical Sciences 2009; 98(4):1577-1586
Ishikawa M, Mu P, Quock RM, Davies NM, Hu XT, Schlüter OM, Dong Y. Homeostatic Synapse-Driven Membrane Plasticity in Nucleus Accumbens Neurons. Journal of Neuroscience. 2009; 29(18): 5820-5831
Vega-Villa KR, Remsberg CM, Yanez JA, Takemoto JK, Andrews PK, Davies NM. Stereospecific high-performance liquid chromatography of taxifolin, applications in pharmacokinetics, and determination in tu fu ling (Rhizoma smilacis glabrae) and apple (Malus x domestica). Biomedical Chromatography 2009 23(6):638-646.
Takemoto JK, Davies NM. High-Performance Liquid Chromatographic Analysis and Preliminary Pharmacokinetic Characterization of 3’-hydroxypterostilbene in Rats. Biomedical Chromatography 2009; 23(10): 1086-1091.
2010
Serve KM, Yáñez JA, Remsberg CM, Davies NM, Black ME. Development and Validation of a Rapid and Sensitive HPLC Method for the Detection of 5-Fluorocytosine (5FC) and Its Metabolites. Biomedical Chromatography 2010; 24: 556-561.
Bertram RM, Takemoto JK, Remsberg CM, Vega-Villa KR, Sablani S, Davies NM. High-performance liquid chromatographic analysis: applications to nutraceutical content and urinary disposition of oxyresveratrol in Biomedical Chromatography. 2010; 24:516-521.
Davies NM, Takemoto JK, Brocks DR, Yanez JA. Multiple Peaking Phenomena in Pharmacokinetic Profiles. Clinical Pharmacokinetics 2010; 49(6): 351-377.
Cai S, Cohen MS, Davies NM, Forrest ML. Pharmacokinetics and Disposition of a Localized Lymphatic Polymeric Hyaluronan Nanoconjugate of Cisplatin in Rodents. Journal of Pharmaceutical Sciences 2010; 99(6): 2664-2671.
Mejia-Meza E, Yáňez JA, Remsberg CM, Takemoto JK, Davies NM, Rasco B, Clary C. The Effect of Dehydration on Raspberries: Polyphenol Retention, Total Polyphenols and Anthocyanins, Antioxidant Activity and Adipogenesis Journal of Food Science 2010; 75(1): H5-H12
Bandyopadhyay A, Espana F, Balla VK , Bose S, Oghami Y, Davies NM. Influence of Porosity on Mechanical Properties and In vivo Response of Ti6Al4V Implants. Acta Biomaterialia 2010; 6: 1640-1648.
Remsberg CM, Good RL, Davies NM. Ingredient Consistency of Commercially Available Polyphenol and Tocopherol Nutraceuticals. Pharmaceutics 2010; 2: 50-60.
Sablani SS, Andrews PK, Davies NM, Walters T, Saez H, Syamaladevi RM, Mohekar PR. Effect of Thermal Treatments on Phytochemicals in Conventionally and Organically Grown Berries. Journal of the Science of Food and Agriculture 2010; 90: 769-778.
Bonin A, Yanez JA, Fukuda C, Teng XW, Hambley TW, Lay PA, Davies NM. Inhibition of Experimental Colorectal Cancer and Reduction in Renal and Gastrointestinal Toxicity by Copper Indomethacin in Rats. Cancer Chemotherapy and Pharmacology 2010; 66(4): 755-764.
Balla VK, Bose S, Davies NM, Bandyopadhyay A. Tantalum – A Bioactive
Metal for Implants. Journal of Minerals, Metals and Materials Society 2010; 62(7): 60-63.
Xie Y, Aillon KL, Cai S, Christian JM, Davies NM, Berkland CJ, Forrest ML. Pulmonary delivery of cisplatin-hyaluronan conjugates via endotracheal instillation for the treatment of lung cancer. International Journal of Pharmaceutics 2010; 392(1-2): 156-163.
Cai S, Thati S, Bagby TR, Diab HM, Davies NM, Cohen MS, Forrest ML. Localized doxorubicin chemotherapy with a biopolymeric nanocarrier improves survival and reduces toxicity in xenografts of human breast cancer. Journal of Controlled Release 2010; 146(2):212-218.
Serve KM, Darnell JL,Takemoto JK, Davies NM, Black ME. Validation of an Isocratic HPLC Method to Detect 2-Fluoro-β-Alanine for the Analysis of Dihydropyrimidine Dehydrogenase Activity. Journal of Chromatography B: Biomedical Applications. 2010; 878(21): 1889-1892.
Banerjee SS, Tarafder MS, Bandyopadhyay A, Bose S, Davies NM. Understanding the Influence of MgO and SrO Binary Doping on Mechanical and Biological Properties of β-TCP Ceramics. Acta Biomaterialia 2010; 6(10): 4167-4174.
Reganold J, Andrews P, Reeve J, Carpenter-Boggs L, Schadt C, Alldredge JR, Ross C, Davies NM, Zhou J. Fruit and Soil Quality of Organic and Conventional Strawberry Agroecosystems. PLoSOne 2010; 5(9): 1-14.
Cai S, Xie Y, Davies NM, Cohen MS, Forrest ML. Carrier-based
intralymphatic cisplatin chemotherapy for the treatment of metastatic squamous cell carcinoma of the head and neck. Therapeutic Delivery 2010; 1(2): 237-245.
Bermudez-Aguirre D, Yanez JA, Dunne CP, Davies NM, Barbosa-Canovas GV. Study of Strawberry Flavored Milk Under Pulsed Electric Field Processing, Food Research International2010; 43: 2201-2207.
Remsberg CM, Yáñez JA, Vega-Villa KR, Miranda ND, Andrews PK, Davies NM. HPLC-UV and LC-ESI-MS Analysis of Phloretin in Biological Fluids and Application to Pharmacokinetics and Analysis of Malus domestica. Journal of Chromatography and Separation Techniques 2010; 1:101. doi:10.4172.
2011
Dittrick S, Balla VK, Davies NM, Bose S, Bandyopadhyay A. In vitro wear rate and Co ion release of compositionally and structurally graded CoCrMo-Ti6Al4V structures. Materials Science and Engineering: C 2011; 31: 809–814.
Sablani SS, Andrews PK, Davies NM, Walters T, Saez H, Bastarrachea L. Effects of Air and Freeze Drying On Phytochemical Content of Conventional and Organic Berries. Drying Technology 2011; 29: 205-216.
Maldonado, AQ, Davies NM, Crow SA, Little C, Ojogho ON, Weeks DL. Effects of Plasmapheresis on Mycophenolic Acid Concentrations in a Patient with Myasthenia Gravis. Transplantation 2011; 91: 1, E3-E4.
Takemoto JK, Davies NM. Method of Analysis of Beta-glucogallin and Gallic Acid: Application to Urinary Pharmacokinetic Studies. Journal of Pharmacy and Biomedical Analysis 2011; 54(4):812-816.
Remsberg CM, Takemoto JK, Bertram RM, Davies NM. High Performance Liquid Chromatography Assay of Gnetol in Rat Serum and Application to Pre-clinical Pharmacokinetic Studies. Journal of Pharmaceutical and Biomedical Analysis 2011; 54(4): 878-881.
Diezi T, Takemoto JK, Davies NM, Kwon GS. Pharmacokinetics and nephrotoxicity of amphotericin B-incorporated poly(ethylene glycol)-block-poly(N-hexyl stearate l-aspartamide) micelles. Journal of Pharmaceutical Sciences 2011; 100(6): 2064-2070.
Vega-Villa KR, Takemoto JK, Remsberg CM, Yanez JA, Davies NM. Stereospecific Pharmacokinetics of Selected Chiral Flavonoids: Taxifolin, Isosakuranetin and Homoeriodictyol and their Disposition in Plants. Chirality 2011; 23(4): 339-348.
Bernard SA, Balla VK, Davies NM, Bose S, Bandyopadhyay A. Bone Cell–materials Interactions and Ni Ion Release of Anodized Equiatomic NiTi Alloy. Acta Biomaterialia 2011; 7(4): 1902-1912.
Yanez JA, Remsberg CM, Sayre CL, Forrest ML, Davies NM. Flip-Flop Pharmacokinetics: Delivering a Reversal of Disposition. Therapeutic Delivery in press May 2011.
Mostafavi A, Emami J, Varshosaz J, Davies NM, Rezazadeh M. Development of a prolonged-release gastroretentive tablet formulation of ciprofloxacin hydrochloride: pharmacokinetic characterization in healthy human volunteers. Int J Pharmaceut on line March 1, 2011 in press 2011.
Bose S, Tarafder S, Banerjee SS, Davies NM, Bandyopadhyay A. Understanding In Vivo Response and Mechanical Property Variation in MgO, SrO and SiO2 doped β-TCP. In press Bone 2011.
Davies NM. Stilbenes Applications in Chemistry, Life Sciences and Materials Science. Applied Organometallic Chemistry (Wileyonlinelibrary.com) DOI 10.1002/aoc.1767, 2011.
Yanez JA, Brocks DR, Forrest ML, Davies NM. Pharmacokinetic Behaviors of Orally Administered Drugs In Oral Bioavailability: Basic Principles, Advanced Concepts and Applications, Wiley Series in Drug Discovery and Development 2- July 2011ISBN-10: 0-470-26099-8 ISBN-13: 978-0-470-26099-9 - John Wiley & Sons
Patents:
Australian Provisional Patent Application No. 2004901694 Entitled "Composition" filed on the 30th March 2004. Subsequently filed as International Patent Application Number PCT/AU2004/00442
Australian Provisional Patent Application No. 2005901463 filed on the 24th March 2005 and entitled Method of Treatment of Carcinomas.
Australian Provisional Patent Application No. 2005901462 filed on the 24th March 2005 and entitled Metal Complexes (Copper ACM complexes)
United States Patent Application filed July 9, 2008 Micellular Encapsulation of Tanespimycin.
World Patent Application WO 2006/099677 A1 filed 2006 and entitled Preparation of transition metal acematicin complexes with anti-inflammatory activity