College of Pharmacy

Pharmaceutical Sciences

Suzanne Lindsey picture

J. Suzanne Lindsey, Ph.D
Associate Professor
Department of Pharmaceutical Sciences
P.O. Box 646534
Washington State University
Pullman, WA 99164-6534
(509) 335-4689 (phone)
(509) 335-5902 (fax)
lindseys@wsu.edu

 

 

Education: Ph.D., Molecular Microbiology and Immunology, Oregon Health Sciences University; Postdoctoral fellow, Oregon Regional Primate Research Center, Portland; B.S. Applied Science, Pacific University, Forest Grove, Ore.

Research Interests: Migration and Invasion in Cancer and Cytotrophoblast Cell Biology.

Research Summary: A primary focus of my laboratory is to determine, characterize and test the feasibility of cancer cell-specific targets and markers in order to detect and treat this disease. We have several promising leads in pursuit of this goal. The lethal phase of cancer is its spread to other parts of the body. This spread, or migration, has been attributed to integrins, receptor tyrosine kinase (RTKs) activation and their respective ligands. However, these proteins are not carcinoma cell specific targets because they are expressed in many normal tissues such as bone, intestine, bone marrow, spleen and muscle to maintain or repair physiology. Using a functional genomic approach, we have isolated several early genes induced by RTK activation of carcinoma cell migration. Currently, we are focusing on the most promising marker and target we have designed as Migration inducing gene 7 (Mig-7); expression that is induced by Hepatocyte growth factor also known as Scatter factor (HGF/SF), epidermal growth factor (EGF) or insulin like growth factor-1 (ILG-1) in concert with _v_5 intergrin ligation. Mig-7 is expressed prior to and during cancer cell migration and invasion. Most importantly, we have not detected, even with RT-PCR (40 cycles) Mig-7 expression in normal tissue (n=6 each site) including brain, heart, kidney, spleen, liver, colon, lung, small intestine, muscle, stomach, testis, term placenta, salivary gland, thyroid, adrenal, pancreas, ovary, uterus, prostate, skin, peripheral blood leukocytes, bone marrow, fetal brain and fetal liver.

Technology GAP transfer grant
Validation of a Diagnostic Blood Assay Using MIG-7 as a Marker to Detect Cancer Cells
PI: J. Suzanne Lindsey

Teaching:
PharmD candidates: Teaches all endocrine topics in Pharmacological Basis of Therapeutics. At Texas Tech University, served as team leader for the Reproductive Pharmacotherapy courses well as a team member in Physiology, Principles of Disease, Drug Design/Discovery in Cancer Therapy and Case Studies I courses for a total of 88 in class hours. Rated as an excellent teacher by at least 70% of the students in each class. Class size, except for case studies, was 74-84 students.

Lab personnel: At WSU, training two undergraduates, one graduate student, one M.S. and one B.S. Trained five PharmD candidates, two pre-med graduates and one high school student in molecular biology techniques at Texas Tech.

Pharmaceutical Sciences graduate students: Thesis committee member for Ashley C. Jones and for Manpreet Chahal graduate students.
At Texas Tech University HSC, served as team leader for the Biotechnology course. Taught in two additional courses: Drug Design and Discovery of anticancer therapies and in Biochemistry, Cell adhesion, homing and metastasis for a total of 18 in class hours. Mentored two graduate students, Celee Spidel and Julie Gaasch, for their respective dissertations in my laboratory. One of my graduate students, Julie Gaasch, won a renewable AFPE Pre-doctoral Fellowship in the Pharmaceutical Sciences, an award at the national level of competition.

Patents:
“Mammalian Migration Inducting Gene and Methods for Detection and Inhibition of migrating tumor cells” – PCT filing: WO 03/066808 A2, published August 14, 2003. Entered national phase July, 2004. Inventor: J. Suzanne Lindsey (Will split into three patents)

Representative Publications:

Gaasch, J. and Lindsey, J.S. (in Press) Analyses of Hepatocyte growth factor-regulated genes in differentiated RAW 264.7 osteoclast-like cells. GENE

Phillips T.M. and Lindsey, J.S. (In Press) Carcinoma Cell-specific Mig-7: A new potential maker for circulating and migrating cancer cells. Oncology Reports.

Crouch S, Spidel CS, Lindsey JS. (2004) HGF and ligation of _v_5 integrin induce a novel, cancer cell-specific gene expression required for cell scattering.
Exp Cell Res. 292(2):274-87.

Lindsey JS, Brenner RM. (2002) Novel hepatocyte growth factor/scatter factor isoform transcripts in the macaque endometrium and placenta. Mol Hum Reprod. 8(1):81-7.

K.A. Sutton, S. Maiti, W.A. Tribley, J.S. Lindsey, M.L. Meistrich, C.D. Bucana, B.M. Sanborn, D.R. Joseph, M.D. Griswold, G.A. Cornwall, M.F. Wilkinson. (1998) Androgen regulation of the Pem homeodomain gene in Sertoli and epididymal cells. Journal of Andrology 19(1):21-30.

R.P. Nhim, J.S. Lindsey, M.F. Wilkerson. (1997) A processed homeobox gene expressed in a stage-, tissue-, and region-specific manner in epididymis. Gene. 185(2):271-276.

Invited Talks
Texas A&M University Health Science Center. Invited by Fuller W. Bazer, Ph.D. Regents Fellow and O.D. Butler Chair in Animal Science Director, Center for Animal Biotechnology Texas A&M University seminar on Friday, March 31, 2000. “Pem: An androgen-regulated homeobox gene expressed in Sertoli cells of the testes and proximal caudal epithelium of the epididymis”

Society of Gynecological Oncology Annual Meeting. Invited by Dr. William Robinson III. “Scatter/Hepatocyte Growth factor induces a carcinoma-specific gene expression in endometrial epithelial cells with alpha(v)beta(5) integrin activation required”. Nashville, TN. 2001.

Van Andel Research Institute at the VARI Seminar Series. Invited by George Vande Woude, Ph.D. Director, October 9, 2002. “Convergence of tyrosine kinase receptor and integrin signaling”

Georgetown University. Invited by Dr. Kathryn Sandberg. Washington, D.C., October 21, 2002. “Convergence of tyrosine kinase receptor and integrin signaling”.

W. Texas A&M University. Invited by Dr. Brenda Rogers and Instructor Cynthia Meador. Canyon, TX, April 14, 2004. “Mig-7: Cancer cell-specific target and marker potential”.

Washington State University, College of Pharmacy. Invited by Dr. Raymond Quock. Pullman, WA. May 3, 2004. “Mig-7: Cancer cell-specific target and marker potential”.

University of Texas San Antonio, School of Medicine, Department of OB/GYN. Invited by Dr. Rajeshwar R. Tekmal. San Antonio, June 2, 2004. “Mig-7: Growth factor regulated, early placenta and cancer cell-specific functions.”

Targeted Diagnostics and Therapeutics Incorporated. Invited by Dr. Daniel O’Shannessy, Chief Operating Officer. West Chester, Pennsylvania, July 15, 2004. “Mig-7: Growth factor regulated, early placenta and cancer cell-specific functions.”

AVIVA Biosciences Incorporated. Invited by Dr. Jia Xu, Vice President of Research and Development. San Diego, California, July 28, 2004. “Mig-7: Growth factor regulated, early placenta and cancer cell-specific functions.”

KPBX public broadcasting. Invited by Doug Nadvornick, News Director. Spokane, Washington, March 15, 2005. Panelist on “Prostate Predicament”

 

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