Salah-uddin Ahmed, Ph.D.

Education
Ph.D. in nutrition and chemoprevention, Hamdard University, Department of Toxicology, New Delhi, India

Master of Science in toxicology, Hamdard University, New Delhi, India

Bachelor of Science in zoology and chemistry, Rajasthan University, Jaipur, India

Additional training
Postdoctoral Fellow, Department of Orthopedics, Case Western Reserve University, Cleveland, Ohio

Teaching
Dr. Salah-uddin Ahmed's teaching activites include central nervous system and endocrine systems pharmacology, toxicology, and drug discovery and development.

Research
Ahmed's primary research interest is in testing the efficiency of the active compound in green tea for treatment of rheumatoid arthritis. People suffering from rheumatoid arthritis tend to develop cardiovascular complications, and Ahmed’s research team also is focused on that complication and studies a specific category of small proteins - cytokines - and the cells that are activated in response to them.

Ahmed’s research is currently funded by grants from the National Institutes of Health, the Arthritis Foundation, and Roche/Genetech.

Recent Research Support
04/01/13-3/31/18 | "Regulation of IL-6 mediated inflammation and tissue destruction by EGCG." NIAMS/NIH R01 AR063104
Principal Investigator: Salah-uddin Ahmed

09/01/11-07/31/14 | "Efficacy of tocilizumab in IL-6 induced dyslipidemia." Roche/Genentech Investigator Initiated Grant
Principal Investigator: Salah-uddin Ahmed

06/01/14 – 05/31/2016 | “Mechanism of Mcl-1 regulation in rheumatoid arthritis.” Arthritis Foundation Innovative Research Grant
Principal Investigator: Salah-uddin Ahmed

Additional Information
Ahmed received his Ph.D. from Hamdard University in New Delhi, India. His research focused on nutrition and chemoprevention. Ahmed worked as an associate research scientist in research and development for the pharmaceutical company Zydus Cadila in India.

After a postdoctoral fellowship in the Department of Orthopedics at Case Western Reserve University School of Medicine in Cleveland, Ohio, Ahmed continued his research work as a research associate in the Department of Medicine, and then moved to the University of Michigan Medical School in Ann Arbor, Mich., to work as a research investigator and then a research assistant professor in the Department of Internal Medicine where he received his first NIH research grant to study the potential therapeutic properties in green tea and its active molecule epigallocatechin-3-gallate (EGCG). Ahmed moved his research into pharmacology at the University of Toledo College of Pharmacy and Pharmaceutical Sciences in 2009, where he spent five years as an assistant professor. Ahmed joined the WSU College of Pharmacy as an associate professor in 2014.

Ahmed serves on several NIH study sections as a grant reviewer and is on the editorial board for the peer-reviewed, open access Journal of Functional Food in Health and Diseases, and serves as an ad hoc reviewer for over 15 other journals including Arthritis and Rheumatism, Biochemical Pharmacology, Toxicology & Applied Pharmacology, and the Journal of Pharmacology and Experimental Therapeutics.

Honors and Awards

2012   ACR/REF-Abbott Health Professional Graduate Preceptorship Award, American College of Rheumatology

2007   Young Scientist Travel Award, American Society for Pharmacology and Experimental Therapeutics

1999   Young Scientist Travel Fellowship, International Union of Pharmacology

1998-99   Doctoral Fellowship for Meritorious Students in Research, Hamdard National Foundation, India

1997-98   Junior Research Fellowship, Council of Scientific and Industrial Research, New Delhi, India

 

Memberships
American College of Rheumatology (Research Member)

American Society for Pharmacology and Experimental Therapeutics

American Association of Colleges of Pharmacy

Inflammation Research Association

Recent Presentations
Green tea extract inhibits CXC chemokine production, but upregulates CXC chemokine receptor expression in RA synovial fibroblasts. Experimental Biology meeting, New Orleans, La., April 18-22, 2009.

Annual meeting of American Association of the Colleges of Pharmacy (AACP), Boston, Mass., July 2009.

Blocking ERK1/2 reduces TNF-α-induced IL-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of IL-18BPa. American College of Rheumatology, Philadelphia, Pa., October 18-23, 2009.

Administration of IL-18BP by gene therapy reduces inflammation in rat AIA. Marotte H, Ruth JH, Ahmed S, Amin MA, Campbell PL, Dudler J, and Koch AE. American College of Rheumatology, Philadelphia, Pa., October 18-23, 2009.

Poster presentation titled “Suppression of CC chemokine production and HMVEC chemotaxis by green tea extract”: Ahmed S, Marotte H, Ruth JH, Campbell PL, Lesch C, and Koch AE. Experimental Biology/FASEB meeting April 24-28, 2010, Anaheim, Calif.

Administration of IL-18BP by gene therapy reduces inflammation and prevents joint destruction via downregulation of MMP-9 in rat AIA. Marotte H, Ahmed S, Ruth JH, Amin MA, Bradquer BJ, Lesch C, and Koch AE. 3rd Annual Meeting of the International Bone & Mineral Research Society 2011 May 7-11, Athens, Greece.

Epigallocatechin-3-gallate inhibits rat adjuvant-induced arthritis partly by upregulating antiinflammatory cytokine synthesis. Ahmed S, Marotte H, Ruth JH, Campbell PL, and Koch AE. Experimental Biology 2011 Meeting April 21-25, Washington D.C.

Mechanism of Fractalkine/CX3CL1 synthesis and shedding in rheumatoid arthritis synovial fibroblasts. Jones BA, Beamer M, Rahman A, Abu-Alaiwi W, Ahmed S. American College of Rheumatology meeting held in November 4-9, 2011 Chicago, Ill.

Induction of apoptosis by pentacyclic triterpenoid-rich fraction of apple peels in rheumatoid arthritis synovial fibroblasts. Ahmed S, Fogle E, Beamer M, Trabbic C, Cottier K. 11th International Conference on Function Foods and Chronic Inflammation, August 21-23, University of San Diego, Calif.

Ahmed S, Walsh L, Singh AK, Beamer M, Sudini K, and Leaman DL. Induction of Pro-Apoptotic Noxa Expression By Ursolic Acid Sensitizes Rheumatoid Arthritis Synovial Fibroblasts to Apoptosis: A Role of Mir-181a. American College of Rheumatology meeting held in November 14-19, 2014 Boston, MA.

Singh AK, Riegsecker S, Umar S, Beamer M, and Ahmed S. Epigallocatechin-3-Gallate (EGCG) Suppresses IL-1β-Induced IL-6 and IL-8 Synthesis By Selectively Inhibiting TAK1 Activation in Human Rheumatoid Arthritis Synovial Fibroblasts. American College of Rheumatology meeting held in November 14-19, 2014 Boston, MA.

Umar S, Hedaya O, Agere S, and Ahmed S. Thymoquinone inhibits TNF-α-induced pro-inflammatory mediators in Rheumatoid arthritis synovial fibroblasts in vitro. Experimental Biology 2015 meeting, Boston, MA.

Akhtar N and Ahmed S. Regulation of ASK-1 expression by microRNA-17 and its correlation with rheumatoid arthritis pathogenesis,” at the Annual EULAR meeting in Rome, Italy, on June 11, 2015.


Peer-Reviewed Publications since 2009
Ahmed S*, Silverman MD, Hubert M, Kwan K, Matuszczak N, Koch AE. Down-regulation of Mcl-1 by epigallocatechin-3-gallate (EGCG) sensitizes rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-alpha (TNF-α)-induced apoptosis. Arthritis Rheum. 60:1282-1293, 2009. [* Corresponding author]

Ahmed S. Biological evidence for the benefit of green tea and EGCG in arthritis. Curr. Rheum. Rev. 5: 259-265, 2009.

Marotte H, Ruth JH, Campbell PJ, Koch AE, Ahmed S. Green tea extract inhibits chemokine production, but upregulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis. Rheumatology 49; 467-479, 2010.

Marotte H, Ahmed S, Ruth JH, Koch AE. Blocking ERK1/2 reduces TNF-α-induced IL-18 bioactivity in rheumatoid arthritis synovial fibroblasts by induction of IL-18BPa. Arthritis Rheum 62:722-731, 2010.

Ahmed S. Emerging role of green tea polyphenol EGCG in rheumatic diseases. Arthritis Res Therap 12: 208, 2010 [Epub: PMID: 20447316].

Ruth JH, Arendt MD, Amin MA, Ahmed S, Marotte H, Rabquer BJ, Lesch C, Lee SH, Koch AE. Expression and Function of CXCL16 in a Novel Model of Gout. Arthritis Rheum 2010 [Epub; PMID: 20506383].

Jones BA, Beamer M, Ahmed S. Fractalkine/CX3CL1: a potential new target for inflammatory diseases. Mol Interv 2010: 10(5); 263-270.

Jones BA, Koch AE, and Ahmed S. Pathological role of Fractalkine/CX3CL1 in rheumatic diseases. Front Immunol 2011: 2; 82.

Jones BA, Beamer M, Rahman A, Abu-Alaiwi W, Ahmed S. Role of ADAM17, p38 MAPK, and proteasome pathway in TNF-α and IFN-γ induced synthesis and shedding of fractalkine/CX3CL1 in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2013; 65(11):2814-25.

Ahmed S, Beamer M, Rahman A, Riegsecker S, Bhansali P, Bellini J, Tillekeratne LMV. Differential effect of a marine-derived class I HDAC inhibitor, largazole, on TNF-α-induced activation of rheumatoid arthritis synovial fibroblasts. Toxicol Appl Pharmacol 2013: 270(2); 87-96.

Riegsecker S, Wiczynski D, Kaplan MJ, Ahmed S. Potential benefits of green tea polyphenol EGCG in the prevention and treatment of vascular inflammation in rheumatoid arthritis. Life Sci. 2013: 93(8); 307-12.

Cottier K, Fogle E, Fox DA, and Ahmed S. Noxa in rheumatic diseases: present understanding and future impact. Rheumatology 2014;53:1539-46.

Ahmed S, Malemud CJ, Koch AE, Athar M, and Taub DD. Cytokines and chemokines: disease models, mechanisms, and therapies. Mediators Inflamm 2014: 296356 [Epub].

Boddu SHS, Alsaab H, Umar S, Bonam SP, Gupta H, Ahmed S. Anti-inflammatory Effects of a Novel Ricinoleic Acid Poloxamer Gel System for Transdermal Delivery, Int J Pharm 2015;479(1):207-211.

Umar S, Hedaya O, Agere S, and Ahmed S. Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation. Toxicol Appl Pharmacol 2015;287(3)299-305.

Singh AK, Umar S, Chourasia M, Riegsecker, and Ahmed S. Regulation of TAK1 activation by epigallocatechin-3-gallate in RA synovial fibroblasts: suppression of K63-linked autoubiquitination of TRAF6. Arthritis Rheumatol [In press].

Nash KM and Ahmed S. Nanomedicine in the ROS-mediated pathophysiology: Applications and clinical advances. Nanomedicine 2015 [Epub].

Book Chapters
Ahmed S, Haqqi TM. Emerging role of green tea in prevention of arthritis. In: Tea and Human Health (Weisberg J, Siddiqi M, eds.). Cambridge, Mass.: CABI Publishing, pp 172-181, 2006.


Updated 04/02/2014     Back to top
photo of Dr. Salah-uddin Ahmed

Associate Professor
Pharmaceutical Sciences

salah.ahmed@wsu.edu
509-368-6566

Office: PBS 411
P.O. Box 1495
Washington State University
Spokane, WA 99210-1495