K. Michael Gibson, Ph.D.
Ph.D. in biochemistry, University of California at San Diego
Master of Science in chemistry, University of Colorado at Boulder
Bachelor of Science in chemistry, University of California at Riverside
Fellowships & Additional Training
Certified Clinical Biochemical Geneticist
Dr. Michael Gibson’s teaching history is founded in biochemistry, genetics and health sciences. He has taught a variety of topics directly related to health sciences throughout his professional career. A selection of his previous courses includes "Human Inborn Errors of Metabolism" and "Biochemical and Molecular Genetics" at Baylor University, and "Molecular Mechanisms of Disease" and the Department of Molecular and Medical Genetics Seminar Series at Oregon Health & Science University. Gibson has given several guest lectures for “Principles of Molecular Medicine” at the University of Pittsburgh’s Graduate School of Public Health, as well as numerous other lectures to audiences of neonatology residents and fellows, medical students, lab medicine faculty, neurology fellows and interns, neuroscience graduate students, and pathology faculty, residents and interns. As Chair of Biological Sciences at Michigan Technological University, Gibson taught biochemistry to undergraduates and graduate students, and a broad course in health to undergraduates.
He has served as mentor or research advisor for Ph.D. candidates at Southern Methodist University, Baylor University, Potchefstroom University (South Africa), and San Diego State University. He has also trained six fellows in biochemical genetics throughout his career.
Gibson is a board-certified clinical biochemical geneticist, and has studied a number of Mendelian disorders of metabolism for the better part of 30 years. His research focus includes understanding the pathophysiology of selected disorders, and developing novel pre-clinical treatment approaches with translational relevance. His laboratory employs pharmacological, cellular and dietary treatment approaches in disorders such as succinic semialdehyde dehydrogenase deficiency, phenylketonuria, maple syrup urine disease, galactosemia and transaldolase deficiency, a defect of the pentose phosphate pathway. His training is in protein chemistry, molecular and neurobiology, neuropharmacology and genetics, and various analytical methodologies. His laboratory is actively interested in hepatic biology and novel approaches to liver regeneration.
Gibson is the chair of the Medical and Scientific Advisory Board of the SSADH Association, which represents children and families affected by Succinic Semialdehyde Dehydrogenase Deficiency (SSADH). Much of his research is focused on this disease.
Gibson joined the Washington State University College of Pharmacy in July 2012. He had been chair of the biological sciences department at Michigan Technology University in Houghton, Mich. Gibson is a past professor at the University of Pittsburgh School of Medicine and the Oregon Health & Science University in Portland.
Positions, Honors & Awards
1984-1986 Postdoctoral Fellow, Dept. Pediatrics, University of California, San Diego, La Jolla, CA
1985-1986 Bank of America-Giannini Foundation Fellow
1986-1988 Assistant Research Biochemist, Dept. Pediatrics, Univ. of California, San Diego, La Jolla, CA
1988-1998 Senior Research Scientist, Institute for Metabolic Disorders, Baylor University Medical Center and Baylor Research Institute, Dallas, Texas
1991-1992 Alexander von Humboldt Foundation Research Fellow, Heidelberg, Germany
1989-1994 Assistant Professor of Biomedical Studies, Baylor University, Waco, Texas
1989-1995 Adjunct Assistant Professor of Biological Sciences, Southern Methodist University, Dallas, TX
1994-1998 Associate Professor of Biomedical Studies, Baylor University, Waco, TX
1995-1998 Adjunct Associate Professor of Biological Sciences, Southern Methodist University, Dallas, TX
1995-1998 Adjunct Associate Professor/Neurology, Univ. Texas Southwestern Medical School, Dallas, TX
1998-2001 Associate Professor, Depts. of Molecular and Medical Genetics and Pediatrics, Oregon Health & Science University, Portland, Oregon
1998-2005 Director, Biochemical Genetics Laboratory, Oregon Health & Science University, Portland, OR
1999-2019 Board Certified Clinical Biochemical Geneticist, American College of Medical Genetics
2001-2005 Professor, Molec. and Medical Genetics, Oregon Health & Science University, Portland, OR
2004- Komrower Memorial Lecturer, Annual Meeting, Society for the Study of Inborn Errors of Metabolism, Amsterdam.
2005-2009 Director, Biochemical Genetics Laboratory, Children’s Hospital of Pittsburgh of UPMC
2005-2009 Professor, Pediatrics, Pathology, Human Genetics, University of Pittsburgh School of Medicine
2009- Pres Professor and Chair, Biological Sciences, Michigan Technological University
2008 NIH Site Visit, PDEGEN (Program in Developmental Endocrinology/Genetics), March 26-28.
Lapalme-Remis S, Lewis E, De Meulemeetser C, Chakraborty P, Gibson KM, Torres CH, Guberman A, Salomons GS, Jakobs C, Ali-Ridha A, Parviz M, Pearl P (2015) Natural History of Succinic Semialdehyde Dehydrdogenase Deficiency through Adulthood. Neurology, in press.
Vogel KR, Ainslie GR, Jansen EEW, Salomons GS, Gibson KM (2015) Torin 1 partially corrects vigabatrin-induced mitochondrial increase in mouse. Ann. Clin. Trans. Neurol. 2(6): 699-706.
Vogel KR, Ainslie GR, Phillips B, Arning E, Bottiglieri T, Shen DD, Gibson KM (2015) Physiological competition of brain phenylalanine accretion: intial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2-/- mice. Mol. Genet. Metab., in press.
Yapici NB, Mandalapu S, Gibson KM, Bi L (2015) Targeted fluorescent probes for detection of oxidative stress in the mitochondria. Bioorg Med Chem Lett. 2015 Jul 9. pii: S0960-894X(15)00715-5. doi: 10.1016/j.bmcl.2015.07.011. [Epub ahead of print]
Yapici NB, Bi Y, Li P, Chen X, Yan X, Mandalapu SR, Faucett M, Jockusch S, Ju J, Gibson KM, Pavan WJ, Bi L (2015) Highly stable and sensitive fluorescent probes (LysoProbes) for lysosomal labeling and tracking. Scientific Reports 5: 8576; doi: 10.1038/srep08576
Vogel KR, Ainslie GR, Phillips B, Arning E, Bottiglieri T, Shen DD, Gibson KM (2015) Physiological competition of brain phenylalanine accretion: initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2-/- mice. Molec. Genet. Metab. Rep. 3: 80-87.
Rodan LH, Gibson KM, Pearl PL (2015) Clinical use of CSF neurotransmitters. Pediatr. Neurol. Jun 11. pii: S0887-8994(15)00279-9. doi: 10.1016/j.pediatrneurol.2015.04.016. [Epub ahead of print] Review.
Pearl PL, Parviz M, Vogel K, Schreiber J, Theodore WH, Gibson KM (2014) Inherited disorders of gamma-aminobutyric acid metabolism and advances in ALDH5A1 mutation identification. Dev. Med. Child Neurol. 2014 Dec 29. doi: 10.1111/dmcn.12668. [Epub ahead of print]
Pearl PL, Koenig MK, Riviello J, Christie M, Averill K, Chung WK, Bain J, Chiriboga CA, Hodgeman R, Parviz M, Gibson KM (2015) Novel intervention in GABA-transaminase deficiency. Ann. Neurol., in press.
Pop A, Janssen EAW, Roos B, Struys EA, Oostendorp J, Louro P, Garcia P, Mandel H, Osaka H, Pearl PL, Gibson KM, Salomons GS (2015) Fast model system for in vitro analysis of GABA-T missense variants. J. Inherit. Metab. Dis., in press.
Ainslie, GR, Vogel KR, Cullen VC, Young SL, Brady TC, Gibson KM (2015) The small molecule aldehyde trap NS2 represents an pharmacological approach to enzyme replacement therapy for SSADH deficiency (SSADHD). Am. J. Hum. Genet., in press.
Ainslie GR, Vogel K, Jansen E, Salomons G, Pedersen D, Gibson KM (2015) Clinical evaluation of gamma hydroxybutyric acid (GHB) and its glucuronide in biological matrices of succinic semialdehyde dehydrogenase deficient patients. FASEB J. 29(1): supplement LB501.
Vogel K, Jansen E, Salomons G, Gibson KM (2015) Selected correction of vigabatrin-related toxicity in mice with adjuvant rapalog intervention. FASEB J. 29(1): supplement LB518.
Birkedahl Falk-Petersen C, Klein AB, Vogel KR, Gibson KM, Wellendorph P (2015) Time- and region-specific down-regulation of high-affinity GHB binding sites in SSADH knock-out mice. Nordic Neuroscience Meeting, Trondheim, Norway, June 10-12.
Vogel, K.R., Jansen, E.E.W., Solomons, G., Gibson, KM Transmission Election Microscopy of Retinal Pigment Epithelium in Vigabatrin-Treated Mice: Enhanced Mitochondrial Numbers Associated with GABA-Elevation and Homocarnosine-Depletion. Brain and Brain PET Vancouver Canada (2015).
Pearl PL, Shukla L, Theodore WH, Jakobs C, Gibson KM (2011) Epilepsy in succinic semialdehyde dehydrogenase deficiency, a disorder of GABA metabolism. Brain Dev Jun 9 [Epub ahead of print] PMID: 21664777
Errington AC, Gibson KM, Crunelli V, Cope DW (2011) Aberrant GABA(A) receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice. PLoS One 2011 Apr 19;6(4):e19021. PMID: 21526163
Hager EJ, Piganelli JD, Tse HM, Gibson KM (2011) Aberrant expression of costimulatory molecules in splenocytes of the mevalonate kinase-deficient mouse model of human hyper-IgD syndrome (HIDS). J Inherit Metab Dis May 24 [Epub ahead of print] PMID: 21607759
Knerr I, Weinhold N, Vockley J, Gibson KM (2011) Advances and challenges in the treatment of branched-chain amino/keto acid metabolic defects. J Inherit Metab Dis Feb 3 [Epub ahead of print] PMID: 21290185
He M, Kratz LE, Michel JJ, Vallejo AN, Ferris L, Kelley RI, Hoover JJ, Jukic D, Gibson KM, Wolfe LA, Ramachandran D, Zwick ME, Vockley J (2011) Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay. J Clin Invest 121: 976-84. PMID: 21285510
Kim KJ, Pearl PL, Jensen K, Snead OC, Malaspina P, Jakobs C, Gibson KM (2011) Succinic semialdehyde dehydrogenase: biochemical-molecular-clinical disease mechanisms, redox regulation, and functional significance. Antioxid Redox Signal 15: 691-718. PMID: 20973619
Kranendijk M, Struys EA, van Schaftingen E, Gibson KM, Kanhai WA, van der Knaap MS, Amiel J, Buist NR, Das AM, de Klerk JB, Feigenbaum AS, Grange DK, Hofstede FC, Holme E, Kirk EP, Korman SH, Morava E, Morris A, Smeitink J, Sukhai RN, Vallance H, Jakobs C, Salomons GS (2010) IDH2 mutations in patients with D-2-hydroxyglutaric aciduria. Science 330: 336. PMID: 20847235
Vardya I, Drasbek KR, Gibson KM, Jensen K (2010) Plasticity of post-synaptic, but not pre-synaptic, GABAB receptors in SSADH deficient mice. Exp Neurol 225: 114-22. PMID: 20570675
Harding CO, Gibson KM (2010) Therapeutic liver repopulation for phenylketonuria. J Inherit Metab Dis 33: 681-7. PMID: 20495959
Acosta MT, Munasinghe J, Pearl PL, Gupta M, Finegersh A, Gibson KM, Theodore WH (2010) Cerebellar atrophy in human and murine succinic semialdehyde dehydrogenase deficiency. J Child Neurol 25:1457-61. PMID: 20445195
Dósa Z, Nieto-Gonzalez JL, Korshoej AR, Gibson KM, Jensen K (2010) Effect of gene dosage on single-cell hippocampal electrophysiology in a murine model of SSADH deficiency (gamma-hydroxybutyric aciduria).
Epilepsy Res 90: 39-46. PMID: 20363598
Knerr I, Gibson KM, Murdoch G, Salomons GS, Jakobs C, Combs S, Pearl PL (2010) Neuropathology in succinic semialdehyde dehydrogenase deficiency. Pediatr Neurol 42: 255-8. PMID: 20304328
Skvorak KJ, Hager EJ, Arning E, Bottiglieri T, Paul HS, Strom SC, Homanics GE, Sun Q, Jansen EE, Jakobs C, Zinnanti WJ, Gibson KM (2009) Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD). Biochim Biophys Acta 1792:1004-10. PMID: 19699299
Skvorak KJ, Paul HS, Dorko K, Marongiu F, Ellis E, Chace D, Ferguson C, Gibson KM, Homanics GE, Strom SC (2009) Hepatocyte transplantation improves phenotype and extends survival in a murine model of intermediate maple syrup urine disease. Mol Ther 17:1266-73. PMID: 19436271
Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H (2009) Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs. J Biol Chem 284:33521-34. PMID: 19759021
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Allen I. White Distinguished Professor and Chair
Experimental & Systems Pharmacology
Office: PBS 347
College of Pharmacy
P.O. Box 1495
Washington State University
Spokane, WA 99210-1495
Lab: PBS 340
205 E. Spokane Falls Blvd.
Spokane, WA 99202