Susan A. Marsh, Ph.D.

Education
Ph.D. in human movement studies, The University of Queensland, Brisbane, Australia

Bachelor of Science (Honours I), The University of Queensland, Brisbane, Australia

Bachelor of Health Science, Griffith University, Gold Coast, Australia

Bachelor of Education (Secondary), Queensland University of Technology, Brisbane, Australia

Additional Training
Postdoctoral Scholar, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, AL

Research Interests

  • Mechanisms of exercise-induced cardioprotection
  • Protein O-GlcNAcylation in the heart
  • Cell signaling events in the heart in response to high fat diets and diabetes

Regular exercise provides protection against cardiovascular disease through a reduction of risk factors such as obesity, hypertension and blood lipids. Acute and short term exercise also provide protection against myocardial infarction (heart attack) by upregulation of protective proteins in heart muscle cells and this is independent of any change in risk factors.

My laboratory investigates the role of post-translational modification of proteins in exercise-induced cardioprotection, in addition to the cardiac response of the O-GlcNAc pathway to high fat diets and diabetes. Experimental techniques include in vivo mouse model (including forced and voluntary exercise training), cell culture, isolated heart perfusion, fluorescent microscopy, western blotting, and PCR.

Selected Publications
Strobel, NA., Fassett, RG., Marsh, SA. and Coombes, JS. Importance of understanding pre-analytical variability in biomarker development International Journal of Cardiology In press, 2011. PMID: 21658784

Matsumoto, A., Mason, SR., Flatscher-Bader, T., Ward, LC., Marsh, SA., Wilce, PA., Fassett, RG. and Coombes, JS. Effects of exercise and antioxidant supplementation on endothelial gene expression International Journal of Cardiology In press, 2011. PMID: 21295869

Marsh, SA. and Chatham, JC. The paradoxical world of protein O-GlcNAcylation: a novel effector of cardiovascular (dys)function Cardiovascular Research 89(3):487-488, 2011. PMID: 21177335

Strobel, NA., Peake, JB., Matsumoto, A., Marsh, SA., Coombes, JS. and Wadley, GD. Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis Medicine and Science in Sports and Exercise 43(6): 1017-1024, 2011. PMID: 21085043

Strobel, NA., Fassett, RG., Marsh, SA. and Coombes, JS. Oxidative stress biomarkers as predictors of cardiovascular disease International Journal of Cardiology 147(2): 191-201, 2011. PMID: 20864194

Marsh, SA., Dell’Italia, LJ. and Chatham, JC. Activation of the hexosamine biosynthesis pathway and protein O-GlcNAcylation modulates hypertrophic and cell signaling pathways in cardiomyocytes from diabetic mice Amino Acids 40(3): 819-28, 2011. PMID: 20676904

Laczy, B., Marsh, SA., Brocks, CA., Wittmann, I. and Chatham, JC. Inhibition of O-GlcNAcase in perfused rat hearts by NAG-thiazolines at the time of reperfusion is cardioprotective in an O-GlcNAc dependent manner American Journal of Physiology – Heart and Circulatory Physiology 299(5): H1715-H1727, 2010. PMID: 20833964

Marsh, SA., Dell’Italia, LJ. and Chatham, JC. Interaction of diet and diabetes on cardiovascular function in rats. American Journal of Physiology – Heart and Circulatory Physiology 296(2): H282–H292, 2009. PMID: 19036853

Marsh, SA., Powell, PC., Agarwal, A., Dell’Italia, LJ. and Chatham, JC. Cardiovascular dysfunction in Zucker obese and Zucker diabetic fatty rats: the role of hydronephrosis. American Journal of Physiology – Heart and Circulatory Physiology 293(1): H292–H298, 2007. PMID: 17351065

Laursen, PB., Marsh, SA., Jenkins, DG. and Coombes, JS. Manipulating training intensity and volume in already well-trained rats: effect on skeletal muscle oxidative and glycolytic enzymes and buffering capacity Applied Physiology, Nutrition and Metabolism 32(3):434-442, 2007. PMID: 17510678

Marsh, SA., Mason, S., Ward, LC. and Coombes, JS. Dietary supplementation of vitamin E and alpha-lipoic acid upregulates cell growth and signaling genes in rat myocardium International Journal of Biomedical Science 2(4): 356-359, 2006.

Marsh, SA., Laursen, PB. and Coombes, JS. Effects of antioxidant supplementation and exercise training on erythrocyte antioxidant enzymes International Journal for Vitamin and Nutrition Research 76(5): 324-331, 2006. PMID: 17245671

Marsh, SA. and Coombes, JS. Vitamin E and alpha-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway Clinical and Applied Thrombosis – Hemostasis 12(2):169-73, 2006. PMID: 16708118

Marsh, SA., Pat, BK., Gobe, GC. and Coombes, JS. Evidence for a non-antioxidant, dose-dependent role of alpha-lipoic acid in caspase-3 and ERK2 activation in endothelial cells Apoptosis 10(3): 657-665, 2005. PMID: 15909127

Marsh, SA. and Coombes, JS. Exercise and the endothelial cell International Journal of Cardiology 99(2): 165-169, 2005. PMID: 15749171

Marsh, SA., Laursen, PB., Pat, BK., Gobe, GC. and Coombes, JS. Bcl-2 in endothelial cells is increased by vitamin E and alpha-lipoic acid supplementation but not exercise training Journal of Molecular and Cellular Cardiology 38(3):445-451, 2005. PMID: 15733904

Sharman JE., Gunaruwan P., Knez WL., Schmitt M., Marsh SA., Wilson GR., Cockcroft JR. and Coombes JS. Alpha-lipoic acid does not acutely affect resistance and conduit artery function or oxidative stress in healthy men British Journal of Clinical Pharmacology 58(3): 243-248, 2004. PMID: 15327583

Marsh, SA. and Jenkins, DG. Physiological responses to the menstrual cycle: implications for the development of heat illness in female athletes Sports Medicine 32(10): 601-614, 2002. PMID: 12141881

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Associate Professor
Experimental and Systems Pharmacology

 

Marsh lab website »

 

susan.marsh@wsu.edu
509-358-7718 (office)
509-368-6715 (lab)

Office: PBS 321
P.O. Box 1495
Washington State University
Spokane, WA 99210-1495

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