Kathryn E. Meier, Ph.D.
Ph.D. in pharmacology, University of Wisconsin, Madison
Bachelor of Arts in biology, cum laude, University of California, San Diego
Current teaching assignments include NEP 510, “Foundations of Cellular Regulation,” and NEP 500, “Professional Preparation.” Dr. Meier also serves as an occasional guest lecturer and helps out in many other courses.
Research in Dr. Meier's laboratory concerns molecular and cellular aspects of signal transuction, with a focus on the interface between phospholipid metabolism and protein phosphorylation. Model systems include several types of cancer cells, including lymphoma, prostate cancer, breast cancer, and ovarian cancer. There is particular interest in lysophosphatidic acid (LPA), a ligand for G protein-coupled receptors, as an autocrine and paracrine mediator of growth and inflammation. Another major focus is the role of phospholipase D2 in cell signaling in cancer cells. PLDs are nutrient sensors that regulate the mTOR pathway, which is important in both nutrition and exercise. Other interests include proteins involved in adhesion signaling (e.g., FAK, CCNs) and their regulation by LPA, epidermal growth factor, and other growth factors. The effects of dietary supplements on cellular signal transduction pathways are also an ongoing area of research.
Gibbs, T.C. and Meier, K.E. Expression and regulation of phospholipase D isoforms in mammalian cell lines. J. Cell Physiol. 182: 77-87, 2000.
Gibbs, T.C., Xie, Y., and Meier, K.E. Regulation of expression of Edg family receptors in human prostate cancer cell lines. Ann. N.Y.A.S. 905: 290-293, 2000.
Ku, H., and Meier, K.E. Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells. J. Biol. Chem. 275: 11333-11340, 2000.
Xie, Y., and Meier, K.E.: Assays for phospholipase D metabolites in mammalian cells. Meth. Enzymol. 344: 294-305, 2001.
Xie, Y., Gibbs, T.C., and Meier, K.E.: Lysophosphatidic acid as an autocrine and paracrine mediator. Biochim. Biophys. Acta, 1582: 270-281, 2001.
Xie, Y., Gibbs, T.C., Mukhin, Y., and Meier, K.E.: Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells. J. Biol. Chem. 277: 32516-32526, 2002.
Xie, Y., and Meier, K.E.: Lysophospholipase D and its role in LPA production. Cell Signal. 16: 975-981, 2004.
Zhang, Z., and Meier, K.E.: New assignments for multi-tasking signal transduction inhibitors. Mol. Pharm. 69: 1510-1512, 2006.
Zhang, Z., Liu, Z., and Meier, K.E.: Lysophosphatidic acid production and response in a corneal epithelial cell line. Am. J. Physiol. Cell Physiol. 291: C1089-C1098, 2006.
Han, S., Knoepp, S.M., Hallman, M., and Meier, K.E.: RasGRP confers the phorbol ester-sensitive phenotype to EL4 lymphoma cells. Mol. Pharm. 71: 314-322, 2007.
Snider, A.J., and Meier, K.E.: Receptor transactivation cascades. Am. J. Physiol. Cell Physiol. 292: C1-C3, 2007.
Knoepp, S.M., Chahal, M.S., Xie, Y., Zhang, Z., Brauner, D.J., Hallman, M.A., Robinson, S.A., Han, S., Imai, M., Tomlinson, S., and Meier, K.E.: Effects of phospholipase D2 expression on adhesion and tumorigenesis in EL4 thymoma cells. Mol. Pharm. 74: 574-584, 2008.
Han, S., and Meier, K.E. Integrated modulation of phorbol ester-induced Raf activation in EL4 lymphoma cells. Cellular Signaling 21: 793-800, 2009.
Gibbs, T.C., Rubio, M.V., Zhang, Z., Xie, Y., Kipp, K.R., and Meier, K.E.: Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells. Prostate 69: 1493-1506, 2009.
Jones, A.C., Zhang, Z., Xie, Y., and Meier, K.E.: Epidermal growth factor increases lysophosphatidic acid production in human ovarian cancer cells: Roles for phospholipase D2 and receptor transactivation. Am. J. Physiol. Cell Physiol. 298: C163-C170, 2010.
Chahal, M.S., Brauner, D, and Meier, K.E.: Effects of phospholipase D2 on EGF receptor response in EL4 lymphoma cells. Pharmaceuticals 3: 2045-2058, 2010.
Zhang Z, Knoepp SM, Sansbury HM, Ku H, Xie Y, Hallman M, Meier KE. Differential expression of FAK and Pyk2 in phorbol ester-sensitive and -resistant EL4 thymoma cells. Clin. Expt. Metastasis 28, 551-565, 2011.
Park, J.J., Rubio, M.V., Zhang, Z., Um, T., Xie, Y., Knoepp, S.M., Snider, A.J., Gibbs, T.C., and Meier, K.E.: Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells. The Prostate 72, 1595-1610, 2012.
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Professor and Associate Dean for Graduate Education
College of Pharmacy
Office: PBS 120 P
Lab: HSB 336
Lab: (509) 358-7774
P.O. Box 1495
Washington State University
Spokane, WA 99210-1495