Shuwen Wang, Ph.D.

Education
Ph.D. in biochemistry, Dartmouth Medical School, Hanover, N.H.

Bachelor of Science in electrophysiology and biophysics, Beijing University, Beijing, China

Patent
Title: Beta-secretase enzyme compositions and methods
Assignee: Elan Pharmaceuticals, Inc. (2000) U. S. Patent No. 6,627,739
Inventors: John Anderson, Guriqbal Basi, Minh Tam Doan, Normand Frigon, John Varghese, Michael Power, Sukanto Power, Gwen Tatsuno, Jay Tung, Shuwen Wang, Lisa McConlogue.

Research

Recent Research Support
07/12 - 06/13 | R01 AI102543 (Co-PI), T-cell immunity to polyomavirus infection

08/04 - 08/14 | R01 GM071725 (Co-PI), Repression of the hTERT gene during cell differentiation

Additional Information

Professional Memberships
American Association for Cancer Research (AACR)
American Association for Advancement of Science (AAAS)

Recent Presentations
"Regulation of human telomerase during development and induction of pluripotency." Developmental Biology and Regenerative Medicine (DBRM) Core. Aug. 25, 2010.

"Regulation of human telomerase during development and nuclear reprogramming." Dept. of C&M Physiology seminar series. Apr. 23, 2010.

"Identifying trans-acting factors for telomerase gene regulation by RNAi-based genetic screening." PSCI Experimental Therapeutics program research talk. Apr. 6, 2010.

Peer-Reviewed Publications since 2009
Zhao Y, Wang S, Cheng D, Zhu J. (2014) Dual roles of c-Myc in the regulation of hTERT gene. Submitted to Nucleic Acids Res.

Zhao Y, Wang S, Zhu J. (2011) A multi-step strategy for BAC recombineering of large DNA fragments. Int J Biochem Mol Biol. 2, 199-206. (Co-first authorship)

Jia W, Wang S, Horner JW, Wang N, Wang H, Gunther EJ, DePinho RA, Zhu J. (2011) A BAC transgenic reporter recapitulates in vivo regulation of human telomerase reverse transcriptase in development and tumorigenesis. FASEB J. 25, 979-989. (Co-first authorship)

Zhu J, Zhao Y, Wang S. (2010) Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein & Cell. 1, 22-32.

Mathew R, Jia W, Sharma A, Zhao Y, Clarke LE, Cheng X, Wang H, Salli U, Vrana KE, Robertson GP, Zhu J, Wang S. (2010) Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. FASEB J. 24, 2702-2715.

Wang S, Hu C, Zhu J. (2010) Distinct and temporal roles of nucleosomal remodeling and histone deacetylation in the repression of the hTERT gene. Mol. Biol. Cell. 21, 821–832.

Zhao Y, Wang S, Popova EV, Grigoryev SA, Zhu J. (2009) Rearrangement of upstream sequences of the hTERT gene during cellular immortalization. Gene, Chromosomes & Cancer 48, 963-974.

Wang S, Zhao Y, Leiby M, Zhu J. (2009) Studying human telomerase gene transcription by a chromatinized reporter generated by recombinase-mediated targeting of a bacterial artificial chromosome. Nucleic Acids Res. 37, e111.

Wang S, Zhao Y, Leiby M, Zhu J. (2009) A new positive/negative selection scheme for precise BAC recombineering. Mol Biotechnol. 42, 110-116.

Wang S, Zhao Y, Hu C, Zhu J. (2009) Differential repression of human and mouse TERT genes during cell differentiation. Nucleic Acids Res. 37, 2618-2629.

Updated 02/10/2014     Back to top
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Clinical Associate Professor
Pharmaceutical Sciences

Director, Genomics Core

shuwen.wang@wsu.edu
509-368-6571

Office: PBS 311
P.O. Box 1495
Washington State University
Spokane, WA 99210-1495