Zhenjia Wang, Ph.D.

Education
Ph.D. in physics, Changchun Institute of Physics, Chinese Academy of Sciences

Fellowships & Additional Training
Postdoctoral Fellowship, Department of Chemistry, University of Rochester, Rochester, N.Y.

Research Assistant Professor, Department of Pharmacology, University of Illinois at Chicago, Chicago, Ill.

Research
Dr. Zhenjia Wang’s research is focused on designing and generating therapeutic nanoparticles used to efficiently and effectively prevent and treat inflammatory diseases based on the understanding of molecular mechanism regulating the interactions between therapeutic nanoparticles and biological systems "in vivo".

Strategy

Research strategy graphic

Methodologies

  • Design and manufacture of therapeutic nanoparticles using nanotechnology.
  • Optical imaging tools (small animal molecular imaging, live cell imaging, laser scanning confocal microscopy, and intravital microscopy)
  • Genetic and pharmacological approaches (knockout mouse models and molecular biology).
  • Acute lung Injury and vascular Inflammation mouse models.
  • Multidisciplinary collaboration at the department and college levels.

Current Projects

graphic: nanoparticle targeting delivery prevents inflammatory diseases

Additional Information
Funding Support: NIH and American Heart Association

Selected Publications
Wang Z
, Li J, Cho J, Malik AB. Albumin Nanoparticle Targeting of Adherent Neutrophils in Peripheral Venules via Fcγ Receptors Prevents Vascular Inflammation. Nature Nanotech. 9, 204-210 (2014).

Wang Z, Malik AB. 2013. Squeezing Nanoparticles across Blood-Endothelial Barriers via Caveolae, Therapeutic Delivery. 4(2), 131-133.

Wang Z, Tiruppathi C, Cho J, Minshall RD, Malik AB. 2011. Delivery of Nanoparticle-complexed Drugs across Vascular Endothelial Barrier via Caveolae. IUBMB Life 63(8), 659-667.

Wang Z, Tiruppathi C, Minshall RD, Malik AB. 2009. Size and Dynamics of Caveolae Studied using Nanoparticles in Living Endothelial Cells. ACS Nano 3(12), 4110-4116.

Zhang Y, Wang Z, Ng M, Rothberg LJ. Conformational Reorganization and Solvation Dynamics of Dendritic Oligothiophenes. J. Phys. Chem. B. 111, 13211. 2007

Wang Z, Rothberg LJ. 2007. Structure and Dynamics of Single Conjugated Polymer Chromophores by Surface-Enhanced Raman Spectroscopy. ACS Nano 1(4), 299-306.

Pan S, Wang Z, Rothberg LJ. 2006. Fluorescence Enhancement of Adsorbed Dye Monolayers by a Silver Nanoparticle Overlayer. J. Phys. Chem. B 110, 173831.

Wang Z, Pedrosa H, Krauss T, Rothberg LJ. 2006. Exciton Binding Energy in Single Walled Carbon Nanotubes. Phys. Rev. Lett. 96, 047403.

Wang Z, Rothberg LJ. 2006. Correlations between Silver Nanostructure Density and Surface Enhanced Raman Scattering. Appl. Phys. B 84, 289.

Wang Z, Samuel IDW. 2005. Energy Transfer from a Polymer Host to a Europium Complex in Light-Emitting Diodes. J. Lumin. 111, 199.

Wang Z, Rothberg LJ. 2005. Origins of Blinking in Single Molecule Raman Spectroscopy. J. Phys. Chem. B 109, 3387.

Wang Z, Pan S, Krauss TD, Du H, Rothberg LJ. 2003. The Structural Basis for Giant Enhancement Enabling Single-molecule Raman Scattering. Proc. Natl. Acad. Sci. USA 100, 8638.

Beeby A, Bettington S, Samuel IDW, Wang Z. 2003. Tuning the Emission of Cyclometalated Iridium Complexes by Simple Ligand Modification. J. Mater. Chem. 13(1), 80.

Chen X, Xu Z, Feng T, Hou Y, Liu S, Deng Z, Wang Z, Feng B, Xu X. 2003. Transient Electroluminescence of Blended Polymer Light-emitting Diodes. Synth. Met. 137, 1137.

More citations since 2001 from Google Scholar.

updated 06/02/2014     Back to top
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Assistant Professor
Pharmaceutical Sciences

zhenjia.wang@wsu.edu
509-368-6563

Office: PBS 315
P.O. Box 1495
Washington State University
Spokane, WA 99210-1495

 

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