Experimental and Systems Pharmacology (ESP)

(previously Clinical Pharmacology Section)

 

Meet the Chair

K. Michael Gibson, Ph.D. K. Michael Gibson, Ph.D.

 

 

 

See Dr. Gibson's faculty bio page for more details.

About our section

Clinical pharmacology -- the science of drugs and their clinical use -- connects laboratory science with medical practice and aims to maximize the positive effects of drugs and minimize the side effects.

Clinical research studies involve human participants and follow specific guidelines.

Translational research promotes interactions between laboratory-based research and population-based research to stimulate a better scientific understanding of human health and disease.

Our goal in ESP is to combine clinical pharmacology with clinical and translational research to develop a department that will form a hub for translational pharmacology research, with an emphasis on bridging drug discovery with clinical practice, or ‘bench with bedside’, via advanced systems pharmacology approaches.

These approaches, which have come to the forefront of all facets of drug development within academia, industry, and regulatory agencies, comprise computational modeling methods, including traditional (compartmental) pharmacokinetic/pharmacodynamic (PK/PD) modeling, physiologically-based PK/PD modeling, and population-based PK/PD modeling. These methods require robust experimentally-derived biochemical and physiologic data, generated from pre-clinical (in vitro and animal) and clinical studies, which are used to develop predictive models of the disposition and action of drugs and other xenobiotics in humans.

Areas of interest for current ESP faculty include pharmacokinetics and pharmacodynamics of centrally-acting therapeutics, the interface between the diet and drug therapy, therapeutics for rare genetic disorders, and identification of therapeutic targets for cardiac hypertrophy.

ESP will be expanding the faculty ranks in areas including:

  1. pharmacokinetic/pharmacodynamic modeling and simulation;
  2. discovery and development of drugs for special or underserved populations;
  3. and biostatistics/epidemiology.

The chair of ESP is K. Michael Gibson. See below for links to current faculty web pages and a comprehensive description or their laboratory and research interests.

Mission of ESP
To transform the science of clinical pharmacology by translating drug discovery and clinical research investigations that transcend scientific boundaries through the application of advanced systems pharmacology.

Vision for ESP
To become a premiere venue for training the next generation of scientific leaders in experimental and translational pharmacology research.

Motto of ESP
Transform. Translate. Transcend.

See individual investigator’s web pages for more details on research activities, grants and publications, personnel, seminars and presentations, and other pertinent details

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